rs183937294
This is a intron variant variant in the PLEKHA7 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
Moderate albuminuria
Salem RM et al. “Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen.” Journal of the American Society of Nephrology : Jasn 30(10):2000-2016 (2019)
Allele G
OR 17.22
p 2.0e-8
N 14,560
Large GWAS
European
Sandholm N et al. “Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease.” Diabetologia 65(9):1495-1509 (2022)
Allele G
OR 0.06
p 2.0e-8
N 20,110
Meta-analysisLarge GWAS
European
About PLEKHA7
Enables delta-catenin binding activity. Involved in epithelial cell-cell adhesion; pore complex assembly; and zonula adherens maintenance. Located in several cellular components, including centrosome; nucleoplasm; and zonula adherens. Part of pore complex. [provided by Alliance of Genome Resources, Jul 2025]
View all PLEKHA7 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…