PLEKHA7

pleckstrin homology domain containing A7

Summary

Enables delta-catenin binding activity. Involved in epithelial cell-cell adhesion; pore complex assembly; and zonula adherens maintenance. Located in several cellular components, including centrosome; nucleoplasm; and zonula adherens. Part of pore complex. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants150 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs889131459	11:16,804,425	C/T	—	likely benign
rs61745332	11:16,805,267	G/A	—	likely benign
rs4757433	11:16,805,342	G/A	—	benign
rs1440223488	11:16,810,641	A/C	—	likely pathogenic
rs576126330	11:16,810,665	G/A	—	uncertain significance
rs1274582739	11:16,810,669	G/A	—	uncertain significance
rs372525564	11:16,810,697	C/T	—	likely benign
rs150714472	11:16,810,755	C/T	—	uncertain significance
rs756792088	11:16,810,781	T/G	—	likely benign
rs778611040	11:16,810,784	A/G	—	likely benign
rs149883568	11:16,810,811	T/G	—	likely benign
rs753744566	11:16,811,324	G/A	—	uncertain significance
rs368334548	11:16,811,329	G/T	—	uncertain significance
rs566443311	11:16,811,363	G/A	—	uncertain significance
rs758985894	11:16,812,358	C/T	—	likely benign
rs746401304	11:16,812,414	C/T	—	uncertain significance
rs116885602	11:16,812,551	C/T	—	benign
rs761414979	11:16,812,560	T/C	—	uncertain significance
rs1241636542	11:16,812,562	G/A	—	uncertain significance
rs756351573	11:16,812,609	G/A	—	likely benign
rs151330542	11:16,812,666	T/A	—	likely benign
rs766869320	11:16,812,676	G/A	—	uncertain significance
rs200617051	11:16,812,713	C/T	—	uncertain significance
rs1372873387	11:16,816,052	T/C	—	uncertain significance
rs369109102	11:16,816,110	C/T	—	likely benign
rs200595484	11:16,816,159	C/T	—	likely benign
rs367736520	11:16,816,231	G/A	—	uncertain significance
rs2134275675	11:16,816,235	G/A	—	uncertain significance
rs750019736	11:16,816,251	C/T	—	likely benign
rs765954495	11:16,816,253	T/C	—	uncertain significance
rs572174648	11:16,816,558	G/A	—	uncertain significance
rs190501066	11:16,816,569	A/G	—	likely benign
rs769596963	11:16,822,511	A/G	—	likely benign
rs149301272	11:16,822,561	T/G	—	uncertain significance
rs202166214	11:16,822,599	T/C	—	likely benign
rs146070013	11:16,822,604	T/C	—	benign
rs200712302	11:16,823,312	C/G	—	uncertain significance
rs216489	11:16,823,736	G/T	—	—
rs186994788	11:16,824,257	G/A	intron variant	—
rs952337506	11:16,824,547	T/C	—	conflicting classifications of pathogenicity
rs34556458	11:16,824,599	T/C	—	likely benign
rs763508929	11:16,824,778	G/C	—	uncertain significance
rs758736201	11:16,824,784	C/T	—	uncertain significance
rs2495679201	11:16,824,835	C/A	—	uncertain significance
rs1417548952	11:16,824,842	T/C	—	uncertain significance
rs1849496525	11:16,834,682	T/C	—	likely pathogenic
rs757826459	11:16,838,356	G/A	—	likely benign
rs536079251	11:16,838,381	T/A	—	uncertain significance
rs1164073630	11:16,838,382	C/T	—	uncertain significance
rs146554999	11:16,838,416	C/A	—	likely benign
rs200631936	11:16,838,460	G/A	—	uncertain significance
rs772989794	11:16,838,501	G/A	—	uncertain significance
rs145036106	11:16,838,526	A/T	—	likely benign
rs2496165119	11:16,838,531	G/T	—	uncertain significance
rs749608660	11:16,838,555	C/T	—	uncertain significance
rs757585124	11:16,838,556	G/A	—	uncertain significance
rs768861538	11:16,838,582	C/T	—	likely pathogenic
rs543269788	11:16,838,628	G/A	—	uncertain significance
rs747058495	11:16,838,633	T/A	—	uncertain significance
rs140249022	11:16,838,641	G/A	—	benign
rs760192362	11:16,838,666	C/T	—	uncertain significance
rs201543002	11:16,838,676	G/A	—	likely pathogenic
rs138081083	11:16,838,679	G/A	—	uncertain significance
rs1259585846	11:16,838,745	T/C	—	uncertain significance
rs2496179431	11:16,838,757	G/C	—	uncertain significance
rs35497498	11:16,838,758	C/T	—	benign
rs112926272	11:16,838,852	G/A	—	uncertain significance
rs1027617	11:16,842,787	G/A	intron variant	—
rs765402603	11:16,847,715	A/G	—	uncertain significance
rs145747179	11:16,847,718	T/C	—	likely benign
rs147371461	11:16,847,782	C/T	—	uncertain significance
rs79411837	11:16,847,807	A/G	—	likely benign
rs776976801	11:16,847,811	G/A	—	uncertain significance
rs576325466	11:16,847,826	C/T	—	uncertain significance
rs1028554048	11:16,847,833	T/C	—	uncertain significance
rs372267404	11:16,847,905	C/T	—	uncertain significance
rs375631588	11:16,847,912	C/T	—	likely benign
rs150070534	11:16,847,937	C/T	—	uncertain significance
rs1850649295	11:16,847,962	C/G	—	uncertain significance
rs200638130	11:16,847,988	T/A	—	uncertain significance
rs761637350	11:16,847,996	C/A	—	uncertain significance
rs771118343	11:16,848,030	C/T	—	likely benign
rs567503249	11:16,848,048	G/A	—	uncertain significance
rs79143472	11:16,848,067	A/G	—	benign
rs377065434	11:16,848,090	G/A	—	uncertain significance
rs146091349	11:16,848,096	T/A	—	uncertain significance
rs751530784	11:16,848,117	C/T	—	uncertain significance
rs567415847	11:16,854,631	G/A	—	—
rs382280	11:16,857,799	C/T	intron variant	—
rs879235701	11:16,863,169	G/A	—	uncertain significance
rs1402182253	11:16,863,196	A/G	—	uncertain significance
rs35873274	11:16,863,210	G/C	—	likely benign
rs35908144	11:16,863,245	G/T	—	benign
rs61755457	11:16,863,247	G/A	—	uncertain significance
rs35068039	11:16,863,259	G/A	—	uncertain significance
rs571849679	11:16,863,272	G/A	—	likely benign
rs366590	11:16,872,440	G/A	intron variant	—
rs144777964	11:16,872,754	C/T	—	uncertain significance
rs1028264032	11:16,872,791	C/T	—	uncertain significance
rs1333501593	11:16,872,800	G/A	—	uncertain significance

Showing 100 of 150 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.