rs185639574
This is a regulatory region variant variant in the SETD6 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
QT interval
Méndez-Giráldez R et al. “GWAS of the electrocardiographic QT interval in Hispanics/Latinos generalizes previously identified loci and identifies population-specific signals.” Scientific Reports 7(1):17075 (2017)
Allele T
OR 2.53
p 7.0e-27
N 15,997
Large GWAS
Hispanic or Latin American
About SETD6
This gene encodes a methyltransferase that adds a methyl group to the histone H2AZ, which is involved in nuclear receptor-dependent transcription. The protein also interacts with several endogenous proteins which are involved in nuclear hormone receptor signaling. A related pseudogene is located on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
View all SETD6 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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