rs187355703

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GWAS Catalog Trait Associations (9)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

serum creatinine amount

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.07

p 1.0e-46

N 394,642

Large GWAS

European

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.10

p 2.0e-22

N 602,615

Major Consortium StudyLarge GWAS

multi-ancestry

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele G

OR 0.07

p 4.0e-35

N 450,015

Large GWAS

multi-ancestry

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)

Allele G

OR 0.09

p 2.0e-31

N 355,731

Major Consortium StudyLarge GWAS

multi-ancestry

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele G

OR 0.08

p 2.0e-13

N 110,051

Large GWAS

European

Davyson E et al. “Metabolomic Investigation of Major Depressive Disorder Identifies a Potentially Causal Association With Polyunsaturated Fatty Acids.” Biological Psychiatry 94(8):630-639 (2023)

Allele G

OR 0.09

p 2.0e-12

N 84,405

Large GWAS

European

urate measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.06

p 9.0e-30

N 394,642

Large GWAS

European

Cho C et al. “Large-scale cross-ancestry genome-wide meta-analysis of serum urate.” Nature Communications 15(1):3441 (2024)

Allele G

OR 0.09

p 9.0e-26

N 1,029,323

Meta-analysisLarge GWAS

multi-ancestry

Major TJ et al. “A genome-wide association analysis reveals new pathogenic pathways in gout.” Nature Genetics 56(11):2392-2406 (2024)

Allele G

OR 0.08

p 4.0e-29

N 630,117

Large GWAS

European

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)

Allele G

OR 0.07

p 5.0e-20

N 355,426

Major Consortium StudyLarge GWAS

multi-ancestry

Tin A et al. “Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.” Nature Genetics 51(10):1459-1474 (2019)

Allele G

OR 0.09

p 3.0e-11

N 288,649

Large GWAS

European

serum urea amount

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.07

p 1.0e-26

N 394,642

Large GWAS

European

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)

Allele G

OR 0.08

p 9.0e-21

N 355,637

Major Consortium StudyLarge GWAS

multi-ancestry

cystatin C measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)

Allele G

OR 0.08

p 1.0e-25

N 355,752

Major Consortium StudyLarge GWAS

multi-ancestry

uric acid measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele G

OR 0.06

p 1.0e-18

N 473,241

Large GWAS

multi-ancestry

chronic kidney disease

Wuttke M et al. “A catalog of genetic loci associated with kidney function from analyses of a million individuals.” Nature Genetics 51(6):957-972 (2019)

Allele G

OR 1.22

p 3.0e-10

N 625,219

Large GWAS

European, NR

serum creatinine amount, glomerular filtration rate

Gorski M et al. “1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.” Scientific Reports 7:45040 (2017)

Allele C

OR 0.02

p 5.0e-10

N 110,517

Meta-analysisLarge GWAS

European

blood urea nitrogen amount

Stanzick KJ et al. “Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals.” Nature Communications 12(1):4350 (2021)

Allele C

OR 0.02

p 1.0e-19

N 852,680

Large GWAS

European

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele C

OR 0.09

p 2.0e-18

N 599,920

Major Consortium StudyLarge GWAS

multi-ancestry

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele C

OR 0.07

p 7.0e-21

N 492,819

Large GWAS

multi-ancestry

glomerular filtration rate

Liu H et al. “Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease.” Nature Genetics 54(7):950-962 (2022)

Allele G

OR 15.59

p 9.0e-55

N 1,508,659

Large GWAS

multi-ancestry

Stanzick KJ et al. “Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals.” Nature Communications 12(1):4350 (2021)

Allele G

OR 0.01

p 4.0e-25

N 1,004,040

Large GWAS

European

Wuttke M et al. “A catalog of genetic loci associated with kidney function from analyses of a million individuals.” Nature Genetics 51(6):957-972 (2019)

Allele G

OR 0.01

p 8.0e-30

N 765,348

Large GWAS

multi-ancestry

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.10

p 5.0e-22

N 571,227

Major Consortium StudyLarge GWAS

multi-ancestry

Loeb GB et al. “Variants in tubule epithelial regulatory elements mediate most heritable differences in human kidney function.” Nature Genetics 56(10):2078-2092 (2024)

Allele G

OR —

β 0.088

p 7.0e-42

N 406,504

Large GWAS

European

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)

Allele G

OR 0.09

p 4.0e-30

N 355,731

Major Consortium StudyLarge GWAS

multi-ancestry

Morris AP et al. “Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies.” Nature Communications 10(1):29 (2019)

Allele G

OR 1.10

p 1.0e-9

N 312,296

Large GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

rs187355703

GWAS Catalog Trait Associations (9)

serum creatinine amount

urate measurement

serum urea amount

cystatin C measurement

uric acid measurement

chronic kidney disease

serum creatinine amount, glomerular filtration rate

blood urea nitrogen amount

glomerular filtration rate

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