rs1878022

This is a regulatory region variant variant in the CMKLR1 gene.

▶

Research that mentions this SNP (1)

▶
Polymorphisms in the IL‐1 gene cluster influence systemic inflammation in patients at risk for acute‐on‐chronic liver failure
AssociationN=279José Alcaraz‐Quiles et al.(2017)· Hepatology

A case-control study of 279 cirrhotic patients (178 with acute-on-chronic liver failure, 101 controls) examining IL-1 gene cluster polymorphisms found that IL-1β rs1143623 CC genotype (OR=0.34) and IL-1ra rs4251961 TC genotype (OR=0.58) were protective against ACLF and associated with lower inflammatory cytokine levels and reduced 28-day mortality. The protective genotypes modulated systemic inflammation through altered IL-1 signaling pathways.

Traits studied:28-day mortalityAcute-on-chronic liver failure (ACLF)Bacterial infectionDecompensated cirrhosisGastrointestinal bleedingHepatic encephalopathySystemic inflammation
PubMedDOIMetascience Observatory

About CMKLR1

Enables adipokinetic hormone binding activity and adipokinetic hormone receptor activity. Involved in several processes, including negative regulation of NF-kappaB transcription factor activity; positive regulation of macrophage chemotaxis; and regulation of calcium-mediated signaling. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all CMKLR1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…