rs188561366

This is a 3 prime utr variant variant in the SPRY3 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

HbA1c measurement

Gu Y et al. “Genetic architecture and risk prediction of gestational diabetes mellitus in Chinese pregnancies.” Nature Communications 16(1):4178 (2025)

Allele C

OR 0.62

p 1.0e-24

N 69,269

Large GWAS

East Asian

About SPRY3

Involved in negative regulation of MAPK cascade. Predicted to be located in cytoplasm and membrane. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

View all SPRY3 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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