rs1906252

This is a intron variant variant.

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GWAS Catalog Trait Associations (9)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

intelligence

Savage JE et al. “Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.” Nature Genetics 50(7):912-919 (2018)
Allele A
OR 11.55
p 7.0e-31
N 269,867
Meta-analysisLarge GWAS
European

phospholipids:total lipids ratio

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele A
OR 0.02
p 6.0e-28
N 450,015
Large GWAS
multi-ancestry

household income

Hill WD et al. “Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income.” Nature Communications 10(1):5741 (2019)
Allele A
OR 0.02
p 1.0e-17
N 286,301
Large GWAS
European

saturated fatty acids to total fatty acids percentage

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele A
OR 0.01
p 2.0e-13
N 450,015
Large GWAS
multi-ancestry

total blood protein measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele A
OR 0.01
p 1.0e-10
N 448,242
Large GWAS
multi-ancestry

social interaction measurement

Day FR et al. “Elucidating the genetic basis of social interaction and isolation.” Nature Communications 9(1):2457 (2018)
Allele C
OR 0.01
p 8.0e-9
N 452,302
Large GWAS
European
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Research that mentions this SNP (1)

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Independent evidence for an association between general cognitive ability and a genetic locus for educational attainment
AssociationN=20,495Joey W. Trampush et al.(2015)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

A GWAS replication study demonstrating that rs1906252 (6q16.1, in an intron of lincRNA RP11-436D23.1) is independently associated with general cognitive ability (g factor) across 20,495 COGENT participants (beta=0.031, p=1.47×10⁻⁴). The minor A allele was associated with higher cognitive scores; meta-analysis combining COGENT and SSGAC (43,381 samples) yielded p=4.94×10⁻⁷. The locus was previously identified in an educational attainment GWAS, confirming shared genetic architecture between cognitive ability and educational outcomes.

Traits studied:Cognitive functionEducational attainmentGeneral cognitive abilityProcessing speed
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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