rs1915919
This variant is located in the KAT2B gene.
▶Research that mentions this SNP (1)
▶A GENOME-WIDE ASSOCIATION STUDY OF CLINICAL SYMPTOMS OF DISSOCIATION IN A TRAUMA-EXPOSED SAMPLEAssociationN=484Erika J. Wolf et al.(2014)· Depression and Anxiety
A genome-wide association study of 484 trauma-exposed individuals identified ten SNPs with suggestive associations (p < 10^-5) with dissociative symptoms (derealization and depersonalization) in PTSD. The strongest association was rs263232 (β = 1.4, p = 6.12 × 10^-7) in ADCY8, and rs71534169 (β = 1.63, p = 3.79 × 10^-6) in DPP6. No SNPs met genome-wide significance. These genes are implicated in synaptic plasticity, memory consolidation, and neuronal excitability, suggesting biological pathways underlying dissociative phenomena.
About KAT2B
CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq, Jul 2008]
View all KAT2B variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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