KAT2B

lysine acetyltransferase 2B

Summary

CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq, Jul 2008]

Known Variants101 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs115257396	3:20,081,348	C/T	—	benign
rs74713463	3:20,081,490	A/G	—	benign
rs115129643	3:20,081,560	C/T	—	benign
rs180843614	3:20,081,801	C/A	—	benign
rs549532136	3:20,081,925	G/A	—	benign
rs2470252333	3:20,081,983	G/C	—	uncertain significance
rs1386983596	3:20,082,028	C/T	—	uncertain significance
rs1051970586	3:20,082,030	G/C	—	uncertain significance
rs1366531500	3:20,082,034	C/T	—	uncertain significance
rs1227332251	3:20,082,049	C/G	—	uncertain significance
rs995249037	3:20,082,073	C/T	—	uncertain significance
rs2470252716	3:20,082,082	A/T	—	uncertain significance
rs1167724402	3:20,082,108	G/A	—	uncertain significance
rs201810024	3:20,082,154	G/A	—	likely benign
rs762742633	3:20,082,180	G/A	—	uncertain significance
rs371548043	3:20,082,187	C/T	—	uncertain significance
rs9849842	3:20,082,354	T/G	—	benign
rs1915919	3:20,083,881	C/A	—	—
rs7620608	3:20,095,378	T/G	—	—
rs9874923	3:20,101,563	C/G	—	—
rs1124376	3:20,108,546	C/T	intron variant	—
rs61440199	3:20,111,546	G/A	intron variant	—
rs115176719	3:20,113,620	G/A	—	benign
rs3021408	3:20,113,830	G/A	—	benign
rs1323593442	3:20,113,848	T/C	—	likely benign
rs200560854	3:20,113,883	C/G	—	uncertain significance
rs555906565	3:20,113,884	C/A	—	likely benign
rs749538432	3:20,113,891	G/C	—	uncertain significance
rs3749180	3:20,113,989	C/A	—	benign
rs3828349	3:20,114,044	C/T	—	benign
rs3828348	3:20,114,048	G/A	—	benign
rs4858758	3:20,117,233	C/T	intron variant	—
rs2293140	3:20,136,611	C/T	—	benign
rs2293141	3:20,136,645	A/T	—	benign
rs2293142	3:20,136,683	T/G	—	benign
rs1575130227	3:20,136,756	T/C	—	likely benign
rs1439822788	3:20,136,880	G/A	—	uncertain significance
rs776654246	3:20,136,891	T/C	—	likely benign
rs12636856	3:20,136,959	A/G	intron variant	benign
rs41285057	3:20,141,265	G/C	—	benign
rs11128939	3:20,141,301	T/G	—	benign
rs62243131	3:20,141,308	A/G	—	benign
rs35424474	3:20,141,356	C/T	—	benign
rs182486173	3:20,141,369	A/G	—	uncertain significance
rs13323791	3:20,141,522	A/G	—	benign
rs11918735	3:20,142,606	G/A	—	benign
rs11714203	3:20,142,666	T/C	—	benign
rs79262878	3:20,142,709	T/G	—	benign
rs1284747711	3:20,142,836	A/G	—	uncertain significance
rs916980498	3:20,142,845	G/A	—	uncertain significance
rs552545462	3:20,142,870	G/A	—	uncertain significance
rs151336172	3:20,142,872	A/C	—	uncertain significance
rs772366442	3:20,142,906	G/A	—	uncertain significance
rs1698908326	3:20,142,923	A/G	—	uncertain significance
rs2470333353	3:20,142,929	G/T	—	uncertain significance
rs4858155	3:20,143,020	C/G	—	benign
rs186900581	3:20,146,591	T/C	intron variant	—
rs370344547	3:20,153,083	C/T	—	likely benign
rs9859493	3:20,153,106	C/T	—	benign
rs778860966	3:20,153,140	G/A	—	uncertain significance
rs1356312243	3:20,153,198	G/A	—	uncertain significance
rs2365793	3:20,153,394	G/A	—	benign
rs78154827	3:20,156,157	A/T	—	benign
rs12490215	3:20,156,185	A/G	—	benign
rs2365794	3:20,156,302	T/C	—	benign
rs199916721	3:20,156,426	G/C	—	uncertain significance
rs17006623	3:20,161,043	G/T	—	benign
rs17006625	3:20,161,096	A/G	—	benign
rs555428888	3:20,161,212	C/T	—	uncertain significance
rs1177291837	3:20,164,186	C/T	—	uncertain significance
rs2470359475	3:20,164,206	G/T	—	uncertain significance
rs771703439	3:20,164,216	G/C	—	uncertain significance
rs577306981	3:20,164,232	C/T	—	uncertain significance
rs1003611326	3:20,164,280	C/T	—	uncertain significance
rs9884012	3:20,164,336	T/G	—	benign
rs3828350	3:20,164,481	G/A	—	benign
rs74808282	3:20,167,265	G/A	—	benign
rs373721059	3:20,167,414	A/C	—	likely benign
rs950116860	3:20,167,505	A/G	—	uncertain significance
rs9848249	3:20,168,788	A/G	—	benign
rs41285061	3:20,168,875	C/G	—	benign
rs141010149	3:20,178,481	G/A	—	likely benign
rs3762631	3:20,181,445	A/G	downstream gene variant	—
rs9860573	3:20,181,484	A/T	—	benign
rs3762632	3:20,181,615	G/T	—	benign
rs3762633	3:20,181,676	T/C	—	benign
rs116196143	3:20,181,809	C/T	—	benign
rs115014362	3:20,181,904	T/C	—	benign
rs759409572	3:20,187,821	T/G	—	uncertain significance
rs2470384582	3:20,187,863	G/C	—	uncertain significance
rs143156951	3:20,187,868	T/A	—	uncertain significance
rs150351875	3:20,187,885	A/C	—	likely benign
rs2686315	3:20,188,008	C/T	—	benign
rs2686314	3:20,188,074	C/T	—	benign
rs9865832	3:20,189,449	G/A	—	benign
rs148960024	3:20,189,472	C/A	—	benign
rs11926045	3:20,189,578	G/A	—	benign
rs2470387106	3:20,189,964	A/G	—	uncertain significance
rs1413435391	3:20,193,837	G/A	—	uncertain significance
rs150884035	3:20,193,948	C/T	—	likely benign

Showing 100 of 101 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.