rs1954787

This is a intron variant variant in the GRIK4 gene.

Key Literature Trait Associations

Citalopram Response

GRIK4 rs1954787 is an intronic variant in the glutamate kainate receptor GluR7 subunit gene. The TT genotype was significantly associated with better treatment response to citalopram in the STAR*D study, one of the largest pharmacogenomic studies of antidepressant efficacy. The mechanism may involve modulation of glutamatergic neurotransmission, which interacts with serotonergic pathways targeted by SSRIs.

Baek JH et al. “Favorable influence of subclinical hypothyroidism on the functional outcomes in stroke patients.” Endocrine Journal 57(1):23-29 (2010)

Allele T

OR —

p 1.0e-6

Preliminary work

SSRI Antidepressant Response

GRIK4 rs1954787 is an intronic variant in the glutamate kainate receptor subunit 4 gene. In the landmark STAR*D trial (n=1,816), the C allele was significantly associated with better citalopram treatment response, with CC homozygotes showing reduced nonresponse risk. A subsequent meta-analysis confirmed the association (OR 1.22, 95% CI 1.04-1.44). The mechanism likely involves modulation of glutamatergic neurotransmission, which interacts with serotonergic pathways targeted by SSRIs.

Paddock S et al. “Association of GRIK4 with outcome of antidepressant treatment in the STAR*D cohort” The American Journal of Psychiatry (2007)

Allele C

OR 1.22

p 2.0e-2

Candidate gene study

▶

ClinVar annotation

Benign★☆☆☆

1 submitter

not specified

View on ClinVar →

▶

Research that mentions this SNP (1)

▶

Pharmacogenetics of Major Depression

ReviewMagnus Lekman et al.(2008)· Molecular Diagnosis & Therapy

This review examines pharmacogenetic findings from the STAR*D trial, a large-scale antidepressant treatment outcome study involving 1953 participants. Key findings include associations of rs1954787 (GRIK4) and rs7997012 (HTR2A) with better treatment response, rs1360780 (FKBP5) with rapid antidepressant response, and rs2818224 (GRIK2, OR ~8) and rs4825476 (GRIA3, OR 1.9) with treatment-emergent suicidal ideation.

Traits studied:Antidepressant Treatment RemissionAntidepressant Treatment ResponseMajor DepressionTreatment-Emergent Suicidal Ideation