GRIK4
glutamate ionotropic receptor kainate type subunit 4
Pharmacogene
Summary
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Known Variants85 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs548764589 | 11:120,381,582 | C/T | — | — |
| rs12278740 | 11:120,423,601 | C/A | — | — |
| rs4297478 | 11:120,435,854 | T/C | regulatory region variant | — |
| rs576496319 | 11:120,489,641 | G/T | — | — |
| rs4245040 | 11:120,520,629 | T/A | — | — |
| rs1893907 | 11:120,524,884 | G/T | — | — |
| rs111487154 | 11:120,531,042 | G/T | — | likely benign |
| rs753839952 | 11:120,531,044 | C/T | — | uncertain significance |
| rs770327575 | 11:120,531,047 | C/T | — | uncertain significance |
| rs370031223 | 11:120,531,065 | C/T | — | uncertain significance |
| rs200538196 | 11:120,531,073 | G/A | — | uncertain significance |
| rs112467423 | 11:120,531,082 | G/A | — | uncertain significance |
| rs116098730 | 11:120,531,096 | C/G | — | benign |
| rs151321288 | 11:120,577,062 | G/A | intron variant | — |
| rs1954787 | 11:120,663,363 | T/C | intron variant | benign |
| rs139978243 | 11:120,673,443 | C/T | — | uncertain significance |
| rs184718356 | 11:120,673,451 | C/T | — | likely benign |
| rs372488720 | 11:120,673,482 | G/A | — | uncertain significance |
| rs1446993194 | 11:120,673,525 | T/G | — | uncertain significance |
| rs147572021 | 11:120,673,547 | G/A | — | benign |
| rs36083836 | 11:120,686,124 | C/G | — | benign |
| rs41297895 | 11:120,690,618 | C/G | — | benign |
| rs760930322 | 11:120,690,624 | C/A | — | uncertain significance |
| rs1953436803 | 11:120,702,597 | T/G | — | uncertain significance |
| rs2496822352 | 11:120,702,651 | C/T | — | uncertain significance |
| rs143215135 | 11:120,702,671 | C/T | — | uncertain significance |
| rs148308915 | 11:120,702,685 | C/T | — | likely benign |
| rs112771462 | 11:120,702,703 | C/T | — | benign |
| rs201876969 | 11:120,707,491 | G/A | — | likely benign |
| rs752261288 | 11:120,732,707 | C/G | — | uncertain significance |
| rs77196263 | 11:120,732,716 | A/G | — | benign |
| rs200233611 | 11:120,732,781 | C/G | — | uncertain significance |
| rs747153656 | 11:120,732,792 | A/G | — | uncertain significance |
| rs2496923295 | 11:120,732,824 | C/T | — | uncertain significance |
| rs373447952 | 11:120,744,783 | G/A | — | likely benign |
| rs767820637 | 11:120,744,802 | G/T | — | uncertain significance |
| rs368653765 | 11:120,744,852 | C/T | — | likely benign |
| rs148410637 | 11:120,744,853 | G/A | — | uncertain significance |
| rs199752302 | 11:120,744,856 | G/A | — | uncertain significance |
| rs140216112 | 11:120,744,881 | C/G | — | uncertain significance |
| rs2496982086 | 11:120,744,886 | A/G | — | uncertain significance |
| rs117994876 | 11:120,744,897 | C/T | — | benign |
| rs368838031 | 11:120,744,922 | C/T | — | uncertain significance |
| rs151091579 | 11:120,744,923 | G/T | — | uncertain significance |
| rs113969837 | 11:120,745,910 | C/T | — | benign |
| rs372673799 | 11:120,745,945 | T/C | — | uncertain significance |
| rs749485821 | 11:120,769,256 | G/A | — | uncertain significance |
| rs745926154 | 11:120,769,274 | A/G | — | uncertain significance |
| rs145645956 | 11:120,769,333 | C/T | — | benign |
| rs137989709 | 11:120,776,197 | G/A | — | uncertain significance |
| rs12797755 | 11:120,809,460 | T/C | — | — |
| rs1429190518 | 11:120,811,120 | C/T | — | uncertain significance |
| rs773827501 | 11:120,811,135 | C/T | — | uncertain significance |
| rs374534079 | 11:120,811,158 | C/T | — | uncertain significance |
| rs2230298 | 11:120,811,161 | G/A | — | benign |
| rs577594273 | 11:120,817,936 | C/T | — | — |
| rs1220329828 | 11:120,823,627 | C/T | — | uncertain significance |
| rs1944162298 | 11:120,827,502 | G/A | — | uncertain significance |
| rs644057 | 11:120,827,609 | A/G | — | benign |
| rs745654095 | 11:120,827,611 | G/T | — | uncertain significance |
| rs534517447 | 11:120,827,644 | G/A | missense variant | uncertain significance |
| rs146000427 | 11:120,827,653 | G/A | — | uncertain significance |
| rs1333262691 | 11:120,831,653 | C/T | — | uncertain significance |
| rs754126138 | 11:120,831,679 | G/A | — | uncertain significance |
| rs139636929 | 11:120,831,733 | G/A | — | uncertain significance |
| rs771623867 | 11:120,833,172 | G/A | — | uncertain significance |
| rs779725288 | 11:120,833,274 | A/G | — | uncertain significance |
| rs749668120 | 11:120,833,397 | G/A | — | likely benign |
| rs12800734 | 11:120,836,754 | G/A | intron variant | — |
| rs757629159 | 11:120,837,900 | G/A | — | likely benign |
| rs201415780 | 11:120,837,936 | A/G | — | uncertain significance |
| rs758712008 | 11:120,838,009 | A/G | — | uncertain significance |
| rs377052814 | 11:120,852,871 | G/A | — | uncertain significance |
| rs9988907 | 11:120,852,890 | T/C | — | benign |
| rs772083937 | 11:120,856,634 | G/A | — | uncertain significance |
| rs762340884 | 11:120,856,680 | C/T | — | uncertain significance |
| rs533619612 | 11:120,856,694 | G/A | — | uncertain significance |
| rs1346343089 | 11:120,856,696 | C/T | — | likely benign |
| rs998404108 | 11:120,856,713 | G/A | — | uncertain significance |
| rs2497419490 | 11:120,856,765 | C/G | — | uncertain significance |
| rs764376984 | 11:120,856,777 | C/T | — | likely benign |
| rs2497419796 | 11:120,856,782 | C/A | — | uncertain significance |
| rs2497421041 | 11:120,856,875 | G/T | — | uncertain significance |
| rs768129356 | 11:120,856,899 | G/T | — | uncertain significance |
| rs1591361217 | 11:120,856,907 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.