rs1958560

This is a intron variant variant in the FUT8 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

advanced glycosylation end product-specific receptor amount

Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)
Allele A
OR 0.23
p 2.0e-63
N 10,708
Large GWAS
European

blood protein amount

Gudjonsson A et al. “A genome-wide association study of serum proteins reveals shared loci with common diseases.” Nature Communications 13(1):480 (2022)
Allele G
OR 0.18
p 8.0e-21
N 5,368
Large GWAS
European

age at menarche

Perry JR et al. “Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.” Nature 514(7520):92-97 (2014)
Allele A
OR 0.03
p 4.0e-8
N 182,413
Large GWAS
European

About FUT8

This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]

View all FUT8 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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