FUT8

fucosyltransferase 8

Summary

This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]

Known Variants132 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs7157006	14:65,828,207	C/T	intergenic variant	—
rs11628611	14:65,828,525	C/T	regulatory region variant	—
rs551609499	14:65,850,735	G/A	—	—
rs11158592	14:65,859,968	G/T	intergenic variant	—
rs6573611	14:65,865,255	G/C	—	—
rs7147624	14:65,865,625	T/G	intergenic variant	—
rs8022053	14:65,867,947	T/C	—	—
rs7150448	14:65,871,502	C/G	—	—
rs2898820	14:65,879,354	T/G	regulatory region variant	—
rs7157109	14:65,900,433	C/G	regulatory region variant	—
rs12892058	14:65,903,441	T/C	intron variant	—
rs10483776	14:65,914,867	A/G	intron variant	—
rs7150094	14:65,936,361	A/G	upstream gene variant	—
rs12894182	14:65,937,889	C/A	coding sequence variant	—
rs187251082	14:65,956,623	A/G	intron variant	—
rs1953415	14:65,988,034	A/C	—	—
rs7153297	14:66,003,466	T/A	intron variant	—
rs2411815	14:66,020,071	A/C	—	—
rs11623662	14:66,021,192	T/C	—	—
rs45549535	14:66,028,065	G/A	—	likely benign
rs1885914678	14:66,028,287	G/T	—	likely benign
rs1885915172	14:66,028,293	G/A	—	likely pathogenic
rs142688407	14:66,028,302	C/T	—	likely benign
rs751527986	14:66,028,307	G/A	—	uncertain significance
rs2140044417	14:66,028,336	G/C	—	uncertain significance
rs2229677	14:66,028,446	A/G	—	benign
rs2502900416	14:66,028,459	T/A	—	uncertain significance
rs181724726	14:66,028,478	C/T	—	uncertain significance
rs369228866	14:66,028,483	C/T	—	uncertain significance
rs3825639	14:66,028,505	T/C	—	benign
rs1958560	14:66,036,795	G/A	intron variant	—
rs543247786	14:66,043,787	C/G	—	—
rs7161123	14:66,052,901	G/C	—	—
rs61987994	14:66,070,733	A/G	intron variant	—
rs4902407	14:66,074,635	T/G	intron variant	—
rs10145146	14:66,075,004	C/G	—	—
rs2073294	14:66,082,493	C/T	—	benign
rs111724718	14:66,082,495	A/G	—	benign
rs8012278	14:66,082,573	A/G	—	benign
rs374142551	14:66,082,678	A/G	—	likely benign
rs369850265	14:66,082,692	A/G	—	likely benign
rs368415291	14:66,082,714	T/G	—	uncertain significance
rs757041953	14:66,082,743	G/A	—	uncertain significance
rs143692136	14:66,082,744	C/T	—	likely benign
rs1383088644	14:66,082,746	T/A	—	uncertain significance
rs373968009	14:66,082,756	G/A	—	likely benign
rs199672764	14:66,082,759	G/C	—	uncertain significance
rs1185403247	14:66,082,775	G/A	—	uncertain significance
rs558545418	14:66,082,779	A/G	—	benign
rs2229678	14:66,082,793	C/A	—	benign
rs1221728277	14:66,082,962	G/A	—	uncertain significance
rs200973027	14:66,082,979	A/G	—	uncertain significance
rs757724110	14:66,083,026	C/T	—	likely benign
rs78083604	14:66,083,066	C/G	—	benign
rs181322184	14:66,083,077	A/G	—	likely benign
rs10483782	14:66,083,170	A/G	—	benign
rs10483783	14:66,083,203	A/G	—	benign
rs9323462	14:66,083,214	G/A	—	benign
rs78684228	14:66,096,004	C/T	—	likely benign
rs117401129	14:66,096,193	G/A	—	likely benign
rs763687153	14:66,096,214	A/G	—	uncertain significance
rs1268964755	14:66,096,217	A/G	—	uncertain significance
rs2503118559	14:66,096,233	A/G	—	uncertain significance
rs376707676	14:66,096,286	C/A	—	uncertain significance
rs35137471	14:66,096,297	A/G	—	benign
rs761440011	14:66,096,309	A/T	—	uncertain significance
rs752039426	14:66,096,336	G/A	—	likely benign
rs73268524	14:66,096,533	A/G	—	benign
rs11158607	14:66,110,797	T/G	intron variant	—
rs200603803	14:66,117,441	A/C	—	—
rs576655068	14:66,135,950	C/A	—	likely benign
rs776199529	14:66,135,996	G/A	—	likely benign
rs2503244084	14:66,135,997	T/C	—	uncertain significance
rs2503244132	14:66,136,005	C/T	—	likely benign
rs764558979	14:66,136,007	A/G	—	uncertain significance
rs1460811017	14:66,136,078	C/T	—	pathogenic
rs758456368	14:66,136,083	A/C	—	likely benign
rs2503244608	14:66,136,112	A/T	—	uncertain significance
rs2503244711	14:66,136,128	G/C	—	uncertain significance
rs2503244764	14:66,136,137	A/G	—	likely benign
rs2140372215	14:66,136,159	T/C	—	uncertain significance
rs35949016	14:66,136,163	C/A	missense variant	benign
rs371271925	14:66,136,185	T/G	—	likely benign
rs183228067	14:66,137,037	A/C	intron variant	—
rs12894902	14:66,161,799	C/T	intron variant	—
rs8018278	14:66,180,088	A/G	intron variant	—
rs10129472	14:66,188,209	C/T	—	benign
rs1425278388	14:66,188,499	T/C	—	uncertain significance
rs375771875	14:66,188,525	G/A	—	uncertain significance
rs2503435357	14:66,188,532	C/T	—	uncertain significance
rs142910369	14:66,188,593	C/G	—	likely benign
rs1334593208	14:66,188,600	C/T	—	pathogenic
rs371242983	14:66,188,609	C/T	—	likely pathogenic
rs750078645	14:66,188,614	G/T	—	likely benign
rs1297536872	14:66,188,666	C/G	—	pathogenic
rs189122599	14:66,188,695	A/C	—	likely benign
rs761750676	14:66,188,727	A/G	—	uncertain significance
rs2503436687	14:66,188,729	C/G	—	uncertain significance
rs4143898	14:66,188,882	A/T	—	benign
rs143783144	14:66,190,865	A/G	—	conflicting classifications of pathogenicity

Showing 100 of 132 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.