rs1977756

This variant is located in the ZCCHC7 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

osteoarthritis, knee

Hatzikotoulas K et al. “Translational genomics of osteoarthritis in 1,962,069 individuals.” Nature 641(8065):1217-1224 (2025)

Allele A

OR 1.03

p 2.0e-9

N 1,316,500

Large GWAS

multi-ancestry

About ZCCHC7

Enables RNA binding activity. Predicted to be involved in nuclear RNA surveillance. Located in cytosol and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

View all ZCCHC7 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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