rs1989796

This variant is located in the GRM3 gene.

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Research that mentions this SNP (2)

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Pharmacogenetic associations of the type-3 metabotropic glutamate receptor (GRM3) gene with working memory and clinical symptom response to antipsychotics in first-episode schizophrenia
AssociationN=61Jeffrey R. Bishop et al.(2015)· Psychopharmacology

This pharmacogenetic study in 61 first-episode schizophrenia patients found that GRM3 rs1468412 TT genotype was associated with worsening spatial working memory performance after antipsychotic treatment (p=0.001, Cohen's d=0.75), while GRM3 rs6465084 AA genotype was associated with improved negative symptoms after treatment (p=0.046). No significant associations were found between COMT Val158Met or DRD2/ANKK1 variants and cognitive or symptom changes.

Traits studied:Antipsychotic responseCognitive performanceFirst-episode schizophreniaNegative symptomsSchizophreniaSpatial working memory
PubMedDOIMetascience Observatory
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Association between type‐three metabotropic glutamate receptor gene (GRM3) variants and symptom presentation in treatment refractory schizophrenia
AssociationN=95Jeffrey R. Bishop et al.(2011)· Human Psychopharmacology: Clinical and Experimental

This candidate gene association study examined 95 treatment-refractory schizophrenia patients genotyped for seven GRM3 markers. Two SNPs (rs1989796 and rs1476455) at the 3' end of the gene were significantly associated with global psychosis symptoms measured by BPRS total scores (rs1476455: CC genotype 55.1±10.4 vs A-carriers 48.3±9.2, F=7.6, p=0.0071; rs1989796: CC genotype 50.1±5.7 vs T-carriers 55.8±10.5, F=7.1, p=0.0091), but not with negative symptoms.

Traits studied:Antipsychotic responseGlobal psychosis symptoms (BPRS)Negative symptoms (SANS)Schizophrenia - treatment refractory symptoms
PubMedDOIMetascience Observatory

About GRM3

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]

View all GRM3 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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