GRM3
glutamate metabotropic receptor 3
Summary
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]
Known Variants53 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs274618 | 7:86,272,016 | T/C | — | — |
| rs274620 | 7:86,272,783 | G/A | — | — |
| rs274622 | 7:86,272,940 | C/T | upstream gene variant | — |
| rs148754219 | 7:86,274,087 | G/A | regulatory region variant | — |
| rs802435 | 7:86,285,652 | G/C | intron variant | — |
| rs802438 | 7:86,286,239 | T/C | intron variant | — |
| rs13242038 | 7:86,314,420 | C/T | intron variant | — |
| rs802456 | 7:86,322,686 | T/C | intron variant | — |
| rs724226 | 7:86,325,374 | A/T | — | — |
| rs2189814 | 7:86,331,756 | T/C | intron variant | — |
| rs2189812 | 7:86,348,999 | C/A | — | — |
| rs917071 | 7:86,353,781 | C/T | intron variant | — |
| rs56763064 | 7:86,394,593 | G/A | — | benign |
| rs1306171048 | 7:86,394,650 | C/A | — | uncertain significance |
| rs2116417020 | 7:86,394,853 | C/T | — | uncertain significance |
| rs6465084 | 7:86,403,475 | A/G | downstream gene variant | — |
| rs752373180 | 7:86,415,720 | C/G | — | uncertain significance |
| rs372311811 | 7:86,415,724 | C/T | — | uncertain significance |
| rs2535194365 | 7:86,415,807 | A/C | — | likely benign |
| rs755835635 | 7:86,415,846 | G/A | — | likely benign |
| rs199508883 | 7:86,415,899 | T/C | — | uncertain significance |
| rs867126491 | 7:86,415,907 | C/T | — | uncertain significance |
| rs753611025 | 7:86,415,924 | G/C | — | likely benign |
| rs2228595 | 7:86,415,987 | C/T | synonymous variant | — |
| rs1200874782 | 7:86,415,995 | C/G | — | uncertain significance |
| rs753191583 | 7:86,416,261 | G/A | — | uncertain significance |
| rs140536799 | 7:86,416,369 | G/A | — | uncertain significance |
| rs10234440 | 7:86,420,377 | T/C | upstream gene variant | — |
| rs2237562 | 7:86,422,232 | T/C | intron variant | — |
| rs12704290 | 7:86,427,626 | G/A | intron variant | — |
| rs1468412 | 7:86,433,451 | A/T | intron variant | — |
| rs17676277 | 7:86,439,740 | T/A | intron variant | — |
| rs149875532 | 7:86,440,467 | T/C | intron variant | — |
| rs17161018 | 7:86,444,931 | G/A | intron variant | — |
| rs2299225 | 7:86,447,580 | T/G | intron variant | — |
| rs17161026 | 7:86,468,254 | A/G | — | benign |
| rs536332070 | 7:86,468,296 | C/A | — | uncertain significance |
| rs112722806 | 7:86,468,303 | G/A | — | likely benign |
| rs745602111 | 7:86,468,314 | A/C | — | uncertain significance |
| rs2535298986 | 7:86,468,329 | C/T | — | uncertain significance |
| rs753853928 | 7:86,468,708 | C/T | — | likely benign |
| rs754710321 | 7:86,468,718 | T/A | — | uncertain significance |
| rs17161027 | 7:86,468,750 | C/T | — | likely benign |
| rs138880384 | 7:86,468,841 | G/A | — | uncertain significance |
| rs112184476 | 7:86,468,858 | C/T | — | benign |
| rs769862932 | 7:86,468,890 | C/A | — | uncertain significance |
| rs1447313554 | 7:86,468,907 | C/A | — | uncertain significance |
| rs761489102 | 7:86,468,937 | G/A | — | uncertain significance |
| rs138568176 | 7:86,469,059 | C/T | — | likely benign |
| rs1989796 | 7:86,474,313 | T/A | — | — |
| rs76035289 | 7:86,479,694 | G/A | — | benign |
| rs773970048 | 7:86,479,855 | C/G | — | uncertain significance |
| rs917480462 | 7:86,479,858 | A/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.