rs2237562
This is a intron variant variant in the GRM3 gene.
▶Research that mentions this SNP (1)
▶Replication study and meta‐analysis of the genetic association of GRM3 gene polymorphisms with schizophrenia in a large Japanese case‐control populationAssociationN=7,712Talal Albalushi et al.(2008)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Replication study and meta-analysis of GRM3 gene polymorphisms (rs274622, rs1468412, rs2299225) in 1,916 Japanese schizophrenia patients and 1,915 controls found no associations with schizophrenia (allelic P=0.68-0.74). Meta-analysis of five case-control studies including >3,000 patients each also failed to support associations previously reported in Japanese and Chinese populations, with pooled odds ratios of 0.99 (rs1468412, P=0.87) and 1.01 (rs2299225, P=0.67).
About GRM3
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]
View all GRM3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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