rs917071
This is a intron variant variant in the GRM3 gene.
▶Research that mentions this SNP (2)
▶Association between type‐three metabotropic glutamate receptor gene (GRM3) variants and symptom presentation in treatment refractory schizophreniaAssociationN=95Jeffrey R. Bishop et al.(2011)· Human Psychopharmacology: Clinical and Experimental
This candidate gene association study examined 95 treatment-refractory schizophrenia patients genotyped for seven GRM3 markers. Two SNPs (rs1989796 and rs1476455) at the 3' end of the gene were significantly associated with global psychosis symptoms measured by BPRS total scores (rs1476455: CC genotype 55.1±10.4 vs A-carriers 48.3±9.2, F=7.6, p=0.0071; rs1989796: CC genotype 50.1±5.7 vs T-carriers 55.8±10.5, F=7.1, p=0.0091), but not with negative symptoms.
▶Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophreniaAssociationN=1,794Kristin K. Nicodemus et al.(2007)· Human Genetics
Case-control and family-based association study in 1,794 individuals (296 cases, 370 controls, and 296 families in NIMH sibling study; 501 cases and 627 controls in German sample) investigating statistical epistasis between COMT polymorphisms (rs2097603, rs4680/Val158Met, rs165599) and SNPs in candidate schizophrenia genes. Found significant gene-gene interactions: three RGS4 SNPs showed increased schizophrenia risk with COMT (LRT P-values 0.02-0.05), six G72/DAOA SNPs exhibited epistasis with COMT, three GRM3 SNPs showed interaction effects, and DISC1 SNPs interacted with COMT Val158Met. Main effects for most candidate genes were null, highlighting the importance of epistatic models in psychiatric genetics.
About GRM3
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]
View all GRM3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…