rs1991401

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GWAS Catalog Trait Associations (10)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body height

Yengo L et al. “A saturated map of common genetic variants associated with human height.” Nature 610(7933):704-712 (2022)

Allele G

OR 0.01

p 5.0e-55

N 5,314,291

Large GWAS

European, Hispanic or Latin American, East Asian, African unspecified, South Asian

pulse pressure measurement

Keaton JM et al. “Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.” Nature Genetics 56(5):778-791 (2024)

Allele G

OR 0.17

p 2.0e-18

N 1,028,980

Large GWAS

multi-ancestry

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele G

OR 0.01

p 8.0e-10

N 506,308

Large GWAS

multi-ancestry

systolic blood pressure

Allele G

OR 0.22

p 5.0e-16

N 1,028,980

Large GWAS

multi-ancestry

Koskeridis F et al. “Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.” Nature Communications 15(1):9827 (2024)

Allele G

OR 0.01

p 7.0e-13

N 1,212,859

Large GWAS

European

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.02

p 1.0e-12

N 425,740

Major Consortium StudyLarge GWAS

European

Pozarickij A et al. “Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults.” Nature Communications 15(1):6265 (2024)

Allele G

OR 0.59

p 4.0e-10

N 100,453

Large GWAS

East Asian

level of killer cell lectin-like receptor subfamily B member 1 in blood serum

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.04

p 2.0e-14

N 47,745

Large GWAS

European

serum albumin amount

Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)

Allele A

OR 0.01

p 9.0e-13

N 928,679

Large GWAS

multi-ancestry

FEV/FVC ratio

Shrine N et al. “Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.” Nature Genetics 55(3):410-422 (2023)

Allele A

OR 6.02

p 2.0e-9

N 588,452

Large GWAS

multi-ancestry

mean arterial pressure

Allele A

OR 0.37

p 3.0e-9

N 100,453

Large GWAS

East Asian

mitochondrial heteroplasmy measurement

Gupta R et al. “Nuclear genetic control of mtDNA copy number and heteroplasmy in humans.” Nature 620(7975):839-848 (2023)

Allele A

OR 0.03

p 4.0e-9

N 63,779

Large GWAS

multi-ancestry

asthma

Han Y et al. “Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma.” Nature Communications 11(1):1776 (2020)

Allele A

OR 1.04

p 1.0e-8

N 303,859

Large GWAS

European

sex hormone-binding globulin measurement

Ruth KS et al. “Using human genetics to understand the disease impacts of testosterone in men and women.” Nature Medicine 26(2):252-258 (2020)

Allele G

OR 0.01

p 1.0e-8

N 180,094

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

rs1991401

GWAS Catalog Trait Associations (10)

body height

pulse pressure measurement

systolic blood pressure

level of killer cell lectin-like receptor subfamily B member 1 in blood serum

serum albumin amount

FEV/FVC ratio

mean arterial pressure

mitochondrial heteroplasmy measurement

asthma

sex hormone-binding globulin measurement

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