rs199501

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GWAS Catalog Trait Associations (10)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

blood protein amount

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele G
OR 0.03
p 6.0e-24
N 325,292
Major Consortium StudyLarge GWAS
multi-ancestry

blood phosphate measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele G
OR 0.03
p 1.0e-18
N 325,141
Major Consortium StudyLarge GWAS
multi-ancestry

white matter integrity, age at assessment

Traylor M et al. “The BS variant of C4 protects against age-related loss of white matter microstructural integrity.” Brain : a Journal of Neurology 145(1):295-304 (2022)
Allele A
OR —
p 8.0e-16
N 31,128
Large GWAS
European

brain age measurement

Zhao X et al. “Regulatory Genomic Circuitry of Brain Age by Integrative Functional Genomic Analyses.” Genomics, Proteomics & Bioinformatics 23(5) (2025)
Allele A
OR 0.20
p 2.0e-13
N 35,702
Large GWAS
European

serum albumin amount

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele G
OR 0.02
p 2.0e-13
N 325,292
Major Consortium StudyLarge GWAS
multi-ancestry

aspartate aminotransferase measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele G
OR 0.02
p 1.0e-12
N 354,541
Major Consortium StudyLarge GWAS
multi-ancestry

white matter integrity

Smith SM et al. “An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank.” Nature Neuroscience 24(5):737-745 (2021)
Allele G
OR 0.08
p 1.0e-12
N 20,860
Major Consortium StudyLarge GWAS
European

alkaline phosphatase measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele G
OR 0.02
p 1.0e-11
N 355,891
Major Consortium StudyLarge GWAS
multi-ancestry

level of serum globulin type protein

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele G
OR 0.02
p 3.0e-10
N 325,292
Major Consortium StudyLarge GWAS
multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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