rs200309755

This variant is located in the TAOK1 gene.

▶

GWAS Catalog Trait Associations (9)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

level of peptidyl-prolyl cis-trans isomerase FKBP1B in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele T

OR 0.05

p 7.0e-19

N 47,745

Large GWAS

European

level of heat shock factor-binding protein 1 in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele T

OR 0.05

p 1.0e-17

N 47,745

Large GWAS

European

mitochondrial DNA measurement

Chong M et al. “GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia.” Elife 11 (2022)

Allele T

OR 0.02

p 2.0e-16

N 395,718

Large GWAS

European, South Asian, African unspecified

calcium-binding and coiled-coil domain-containing protein 2 measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele T

OR 0.05

p 8.0e-15

N 47,745

Large GWAS

European

level of protein sprouty homolog 2 in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele T

OR 0.04

p 3.0e-13

N 47,745

Large GWAS

European

level of hematopoietically-expressed homeobox protein HHEX in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele T

OR 0.04

p 4.0e-13

N 47,745

Large GWAS

European

level of misshapen-like kinase 1 in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele T

OR 0.04

p 4.0e-13

N 47,745

Large GWAS

European

level of jupiter microtubule associated homolog 2 in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele T

OR 0.04

p 6.0e-12

N 47,745

Large GWAS

European

level of pleckstrin homology domain-containing family O member 1 in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele T

OR 0.04

p 1.0e-11

N 47,745

Large GWAS

European

About TAOK1

Enables alpha-tubulin binding activity; beta-tubulin binding activity; and kinase activity. Involved in several processes, including mitotic G2 DNA damage checkpoint signaling; negative regulation of microtubule depolymerization; and positive regulation of MAPK cascade. Located in several cellular components, including microtubule cytoskeleton; nuclear body; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

rs200309755

GWAS Catalog Trait Associations (9)

level of peptidyl-prolyl cis-trans isomerase FKBP1B in blood

level of heat shock factor-binding protein 1 in blood

mitochondrial DNA measurement

calcium-binding and coiled-coil domain-containing protein 2 measurement

level of protein sprouty homolog 2 in blood

level of hematopoietically-expressed homeobox protein HHEX in blood

level of misshapen-like kinase 1 in blood

level of jupiter microtubule associated homolog 2 in blood

level of pleckstrin homology domain-containing family O member 1 in blood

About TAOK1

Community Wiki

Comments