rs2003241

▶

GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

hip bone mineral density, hip bone size

Zhang H et al. “Pleiotropic loci underlying bone mineral density and bone size identified by a bivariate genome-wide association analysis.” Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the Usa 31(9):1691-1701 (2020)
Allele T
OR —
p 4.0e-8
N 6,175
Large GWAS
multi-ancestry
▶

Research that mentions this SNP (1)

▶
Polymorphisms in tissue inhibitors of metalloproteinases‐2 and ‐3 and breast cancer susceptibility and survival
AssociationN=2,131Neeraja B. Peterson et al.(2009)· International Journal of Cancer

Population-based case-control study in Chinese women examining TIMP-2 and TIMP-3 polymorphisms with breast cancer susceptibility and survival. TIMP-2 rs7501477 TT genotype increased breast cancer risk (OR 2.9, 95% CI 1.2-7.0). TIMP-3 rs8136803 TT genotype significantly increased breast cancer risk (OR 5.1, 95% CI 1.1-24.3) and worsened disease-free survival (HR 3.9, 95% CI 1.4-10.6), while rs9609643 AA genotype showed protective effect (OR 0.4, 95% CI 0.2-1.0).

Traits studied:breast cancer survivalbreast cancer susceptibilitydisease-free survivaloverall survival
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…