rs206018

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

psoriasis

Zhang M et al. “Multi-ancestry genome-wide meta-analysis with 472,819 individuals identifies 32 novel risk loci for psoriasis.” Journal of Translational Medicine 23(1):133 (2025)
Allele C
OR 0.13
p 4.0e-22
N 472,819
Meta-analysisLarge GWAS
multi-ancestry

level of endophilin-A3 in blood serum

Surapaneni A et al. “Identification of 969 protein quantitative trait loci in an African American population with kidney disease attributed to hypertension.” Kidney International 102(5):1167-1177 (2022)
Allele G
OR 0.60
p 7.0e-17
N 466
Small GWAS
African American or Afro-Caribbean

complement C4 measurement

Thareja G et al. “Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations.” Human Molecular Genetics 32(6):907-916 (2023)
Allele G
OR 0.35
p 4.0e-14
N 2,935
Large GWAS
Greater Middle Eastern (Middle Eastern, North African or Persian)

level of ribonuclease T2 in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.04
p 9.0e-12
N 47,745
Large GWAS
European
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Research that mentions this SNP (1)

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Prognostic value of Notch receptors in postsurgical patients with hepatitis B virus‐related hepatocellular carcinoma
AssociationN=465Tingdong Yu et al.(2017)· Cancer Medicine

Candidate gene study of 465 HBV-related hepatocellular carcinoma (HCC) patients examined 19 SNPs in Notch pathway receptors (NOTCH1-4) using Sanger sequencing. Four SNPs significantly associated with overall survival: rs1043996 (NOTCH3), rs422951 (NOTCH4), rs520692 (NOTCH4), and rs3830041 (NOTCH4). Notch3 mRNA was significantly elevated in tumors (P<0.0001) and higher expression predicted poorer overall and recurrence-free survival.

Traits studied:Hepatocellular carcinoma (HBV-related)Overall survivalRecurrence-free survival
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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