rs2073838
This is a regulatory region variant variant in the SLC22A4 gene.
▶ClinVar annotation
▶Research that mentions this SNP (1)
▶Investigation of the SLC22A4 gene (associated with rheumatoid arthritis in a Japanese population) in a United Kingdom population of rheumatoid arthritis patientsAssociationN=180Anne Barton et al.(2005)· Arthritis & Rheumatism
This study examined the association of SLC22A4 gene polymorphisms rs3792876 and rs2073838 with bronchodilator response to salbutamol in 180 Egyptian asthmatic patients. The homozygous recessive genotype of rs3792876 was significantly more frequent in non-responders (P = 0.01, OR 1.2-9.5), suggesting this variant may influence drug absorption. The rs2073838 polymorphism showed no significant association with bronchodilator response.
About SLC22A4
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent. [provided by RefSeq, Jul 2008]
View all SLC22A4 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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