SLC22A4
solute carrier family 22 member 4
Summary
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent. [provided by RefSeq, Jul 2008]
Known Variants152 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs162887 | 5:131,629,165 | A/T | — | — |
| rs460089 | 5:131,629,772 | C/A | — | — |
| rs460271 | 5:131,630,062 | G/C | — | benign |
| rs11568501 | 5:131,630,300 | A/T | — | likely benign |
| rs1262239243 | 5:131,630,340 | C/T | — | likely benign |
| rs1325651731 | 5:131,630,352 | G/A | — | uncertain significance |
| rs747086200 | 5:131,630,387 | C/T | — | likely benign |
| rs372949734 | 5:131,630,404 | A/G | — | uncertain significance |
| rs774216692 | 5:131,630,443 | C/T | — | uncertain significance |
| rs767014071 | 5:131,630,447 | G/A | — | likely benign |
| rs531041134 | 5:131,630,467 | C/G | — | uncertain significance |
| rs375954722 | 5:131,630,468 | G/C | — | likely benign |
| rs1580814677 | 5:131,630,471 | C/T | — | likely benign |
| rs189072785 | 5:131,630,490 | G/A | — | uncertain significance |
| rs749095440 | 5:131,630,518 | G/C | — | uncertain significance |
| rs1399258798 | 5:131,630,525 | G/C | — | likely benign |
| rs768427012 | 5:131,630,527 | A/G | — | uncertain significance |
| rs2126694567 | 5:131,630,534 | C/T | — | likely benign |
| rs889078678 | 5:131,630,573 | C/T | — | likely benign |
| rs1422706018 | 5:131,630,576 | C/T | — | likely benign |
| rs752151457 | 5:131,630,594 | C/T | — | likely benign |
| rs757815454 | 5:131,630,595 | G/C | — | uncertain significance |
| rs780199805 | 5:131,630,622 | C/G | — | uncertain significance |
| rs768484124 | 5:131,630,647 | G/A | — | uncertain significance |
| rs11568502 | 5:131,630,648 | C/T | — | likely benign |
| rs1304248566 | 5:131,630,703 | G/A | — | uncertain significance |
| rs35260072 | 5:131,630,852 | A/C | — | benign |
| rs419291 | 5:131,633,355 | T/C | upstream gene variant | — |
| rs3792876 | 5:131,637,309 | C/T | intron variant | risk factor |
| rs270612 | 5:131,637,338 | G/A | intron variant | — |
| rs72795121 | 5:131,638,324 | T/A | intron variant | — |
| rs6860806 | 5:131,640,536 | G/A | — | benign |
| rs270613 | 5:131,640,583 | A/T | — | — |
| rs270614 | 5:131,640,813 | G/A | intron variant | — |
| rs270615 | 5:131,641,573 | G/T | — | — |
| rs996458872 | 5:131,647,877 | C/T | — | likely benign |
| rs2531992915 | 5:131,647,891 | T/C | — | uncertain significance |
| rs1028206607 | 5:131,647,901 | C/A | — | benign |
| rs1286049834 | 5:131,647,905 | T/C | — | uncertain significance |
| rs375482214 | 5:131,647,911 | G/A | — | uncertain significance |
| rs201822770 | 5:131,647,916 | C/T | — | likely benign |
| rs11568511 | 5:131,647,925 | C/T | — | benign |
| rs141478353 | 5:131,647,926 | G/A | — | uncertain significance |
| rs11568509 | 5:131,647,935 | G/A | — | uncertain significance |
| rs11568510 | 5:131,647,954 | A/G | missense variant | — |
| rs768389161 | 5:131,647,956 | A/G | — | uncertain significance |
| rs773811534 | 5:131,647,957 | G/C | — | uncertain significance |
| rs270607 | 5:131,649,186 | G/A | — | benign |
| rs2073838 | 5:131,649,222 | G/A | regulatory region variant | benign |
| rs139192595 | 5:131,649,287 | T/C | — | benign |
| rs753395519 | 5:131,649,292 | T/C | — | likely benign |
| rs11568499 | 5:131,649,300 | T/C | — | benign |
| rs781510670 | 5:131,649,323 | G/A | — | conflicting classifications of pathogenicity |
| rs144031153 | 5:131,649,332 | G/A | — | uncertain significance |
| rs369071242 | 5:131,649,354 | G/A | — | uncertain significance |
| rs1750248775 | 5:131,649,367 | G/C | — | likely benign |
| rs753702919 | 5:131,649,393 | T/C | — | uncertain significance |
| rs754580524 | 5:131,649,400 | T/A | — | likely benign |
| rs11568498 | 5:131,649,415 | C/T | — | benign |
| rs2531995957 | 5:131,649,422 | A/G | — | uncertain significance |
| rs11568500 | 5:131,649,424 | G/A | missense variant | — |
| rs373520579 | 5:131,649,438 | A/G | — | uncertain significance |
| rs143879161 | 5:131,649,439 | C/G | — | uncertain significance |
| rs148604311 | 5:131,649,443 | G/A | — | uncertain significance |
| rs376697042 | 5:131,649,448 | A/G | — | likely benign |
| rs1750254142 | 5:131,649,479 | G/A | — | likely benign |
| rs11950562 | 5:131,652,529 | A/T | — | — |
| rs3761659 | 5:131,657,784 | G/C | — | benign |
| rs143140136 | 5:131,657,904 | G/A | — | uncertain significance |
| rs146705097 | 5:131,657,923 | A/T | — | uncertain significance |
| rs2126722754 | 5:131,657,934 | C/A | — | uncertain significance |
| rs751368946 | 5:131,657,968 | G/C | — | likely benign |
| rs776844663 | 5:131,657,971 | T/C | — | likely benign |
| rs370379416 | 5:131,657,989 | C/T | — | likely benign |
| rs768533971 | 5:131,657,993 | C/A | — | likely benign |
| rs1173183721 | 5:131,658,010 | G/A | — | likely benign |
| rs144122563 | 5:131,658,016 | G/A | — | likely benign |
| rs199535716 | 5:131,658,021 | C/T | — | uncertain significance |
| rs1050015260 | 5:131,658,067 | C/T | — | likely benign |
| rs270600 | 5:131,658,085 | T/C | — | benign |
| rs273917 | 5:131,659,618 | A/T | — | — |
| rs273914 | 5:131,660,431 | A/G | — | — |
| rs273913 | 5:131,661,156 | T/A | — | — |
| rs749097547 | 5:131,662,954 | T/A | — | likely benign |
| rs11568503 | 5:131,662,989 | C/T | stop gained | — |
| rs772796676 | 5:131,663,002 | C/G | — | uncertain significance |
| rs2532023230 | 5:131,663,017 | G/C | — | uncertain significance |
| rs746475008 | 5:131,663,019 | G/A | — | uncertain significance |
| rs1459227779 | 5:131,663,031 | A/G | — | uncertain significance |
| rs776363804 | 5:131,663,037 | C/A | — | uncertain significance |
| rs774759030 | 5:131,663,057 | C/T | — | likely benign |
| rs272893 | 5:131,663,062 | T/C | missense variant | benign |
| rs750523509 | 5:131,663,082 | T/C | — | uncertain significance |
| rs199537349 | 5:131,664,529 | T/C | — | — |
| rs200800380 | 5:131,664,531 | T/G | — | — |
| rs13166503 | 5:131,664,592 | A/G | — | — |
| rs56083751 | 5:131,664,638 | T/C | — | — |
| rs272889 | 5:131,665,378 | A/T | — | — |
| rs273909 | 5:131,667,353 | A/G | intron variant | benign |
| rs747845431 | 5:131,667,433 | A/G | — | likely benign |
Showing 100 of 152 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.