rs6860806

This variant is located in the SLC22A4 gene.

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GWAS Catalog Trait Associations (8)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

arachidoylcarnitine (C20) measurement

Chen Y et al. “Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.” Nature Genetics 55(1):44-53 (2023)
Allele G
OR 0.13
p 2.0e-15
N 7,682
Large GWAS
European

fatty acid amount

Sun Y et al. “GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.” Hgg Advances 6(4):100470 (2025)
Allele A
OR —
p 6.0e-12
N 239,268
Large GWAS
European

palmitoleoylcarnitine (C16:1) measurement

Chen Y et al. “Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.” Nature Genetics 55(1):44-53 (2023)
Allele G
OR 0.09
p 2.0e-10
N 8,263
Large GWAS
European

psoriasis

Zhang M et al. “Multi-ancestry genome-wide meta-analysis with 472,819 individuals identifies 32 novel risk loci for psoriasis.” Journal of Translational Medicine 23(1):133 (2025)
Allele A
OR 0.06
p 1.0e-9
N 472,819
Meta-analysisLarge GWAS
multi-ancestry

acne

Teder-Laving M et al. “Genome-wide meta-analysis identifies novel loci conferring risk of acne vulgaris.” European Journal of Human Genetics : Ejhg 32(9):1136-1143 (2024)
Allele G
OR 1.05
p 2.0e-8
N 399,413
Meta-analysisLarge GWAS
European
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ClinVar annotation

Benign★☆☆☆
1 submitter1 publication
View on ClinVar →

About SLC22A4

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent. [provided by RefSeq, Jul 2008]

View all SLC22A4 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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