rs2074356
This is a intron variant variant in the HECTD4 gene.
▶GWAS Catalog Trait Associations (17)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (17)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
serum gamma-glutamyl transferase measurement
Kim YJ et al. “Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.” Nature Genetics 43(10):990-5 (2011)
Allele T
OR 0.02
p 3.0e-126
N 12,545
Large GWAS
East Asian
alcohol drinking
Baik I et al. “Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men.” The American Journal of Clinical Nutrition 93(4):809-16 (2011)
Allele T
OR 1.06
p 9.0e-59
N 1,721
Large GWAS
East Asian
alcohol consumption quality, alcohol drinking
Jorgenson E et al. “Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study.” Molecular Psychiatry 22(9):1359-1367 (2017)
Allele A
OR 2.41
p 6.0e-48
N 86,627
Large GWAS
multi-ancestry
high density lipoprotein cholesterol measurement
Kim YJ et al. “Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.” Nature Genetics 43(10):990-5 (2011)
Allele T
OR 0.04
p 7.0e-37
N 12,545
Large GWAS
East Asian
esophageal carcinoma
Wu C et al. “Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.” Nature Genetics 43(7):679-84 (2011)
Allele T
OR 1.56
p 2.0e-31
N 4,075
Large GWAS
East Asian
body mass index
Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)
Allele A
OR 0.07
p 3.0e-31
N 153,950
Large GWAS
East Asian
body weight
Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)
Allele A
OR 0.04
p 2.0e-21
N 153,950
Large GWAS
East Asian
blood urea nitrogen amount
Lee DJ et al. “Genome-wide association study and fine-mapping on Korean biobank to discover renal trait-associated variants.” Kidney Research and Clinical Practice 43(3):299-312 (2024)
Allele A
OR 0.02
p 5.0e-18
N 58,406
Large GWAS
East Asian
glomerular filtration rate
Lee DJ et al. “Genome-wide association study and fine-mapping on Korean biobank to discover renal trait-associated variants.” Kidney Research and Clinical Practice 43(3):299-312 (2024)
Allele A
OR 0.81
p 2.0e-17
N 58,406
Large GWAS
East Asian
type 2 diabetes mellitus
Go MJ et al. “New susceptibility loci in MYL2, C12orf51 and OAS1 associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes in the Korean population.” Journal of Human Genetics 58(6):362-5 (2013)
Allele T
OR 0.32
p 1.0e-16
N 7,696
Large GWAS
East Asian
Kim YS et al. “Lifestage Sex-Specific Genetic Effects on Metabolic Disorders in an Adult Population in Korea: The Korean Genome and Epidemiology Study.” International Journal of Molecular Sciences 23(19) (2022)
Allele T
OR 0.80
p 1.0e-11
N 50,808
Large GWAS
East Asian
About HECTD4
Predicted to enable ubiquitin-protein transferase activity. Involved in glucose homeostasis and glucose metabolic process. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all HECTD4 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…