rs2102923

This is a intron variant variant in the EXD2 gene.

GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

feeling emotionally hurt measurement

Nagel M et al. Item-level analyses reveal genetic heterogeneity in neuroticism. Nature Communications 9(1):905 (2018)
Allele A
OR 5.77
p 8.0e-9
N 372,047
Large GWAS
European

About EXD2

Enables 3'-5' exonuclease activity; metal ion binding activity; and protein homodimerization activity. Involved in DNA double-strand break processing; double-strand break repair via homologous recombination; and replication fork processing. Located in intermediate filament cytoskeleton; mitochondrial outer membrane; and site of DNA damage. [provided by Alliance of Genome Resources, Jul 2025]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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