EXD2
exonuclease 3'-5' domain containing 2
Summary
Enables 3'-5' exonuclease activity; metal ion binding activity; and protein homodimerization activity. Involved in DNA double-strand break processing; double-strand break repair via homologous recombination; and replication fork processing. Located in intermediate filament cytoskeleton; mitochondrial outer membrane; and site of DNA damage. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants52 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2102923 | 14:69,662,105 | A/G | intron variant | — |
| rs552767609 | 14:69,669,990 | A/C | — | — |
| rs1218590339 | 14:69,676,275 | C/T | — | uncertain significance |
| rs770207941 | 14:69,676,278 | C/T | — | uncertain significance |
| rs182466488 | 14:69,676,279 | G/C | — | uncertain significance |
| rs752389207 | 14:69,676,315 | C/T | — | uncertain significance |
| rs1170685147 | 14:69,676,326 | G/T | — | uncertain significance |
| rs1368124558 | 14:69,676,335 | A/G | — | uncertain significance |
| rs537950944 | 14:69,676,386 | A/G | — | uncertain significance |
| rs1004874222 | 14:69,676,393 | C/T | — | uncertain significance |
| rs1215796570 | 14:69,676,404 | C/T | — | uncertain significance |
| rs1028277326 | 14:69,676,479 | G/A | — | uncertain significance |
| rs1313773946 | 14:69,676,492 | T/C | — | uncertain significance |
| rs779199657 | 14:69,676,494 | C/T | — | uncertain significance |
| rs769308734 | 14:69,695,609 | G/A | — | uncertain significance |
| rs774146343 | 14:69,695,627 | G/A | — | uncertain significance |
| rs142856571 | 14:69,695,743 | G/C | — | uncertain significance |
| rs537752586 | 14:69,695,768 | G/A | — | uncertain significance |
| rs2503346355 | 14:69,697,193 | A/T | — | uncertain significance |
| rs781102008 | 14:69,697,226 | C/T | — | uncertain significance |
| rs775526650 | 14:69,697,229 | G/A | — | uncertain significance |
| rs200378483 | 14:69,697,275 | G/A | — | uncertain significance |
| rs374447986 | 14:69,697,284 | A/G | — | uncertain significance |
| rs546218193 | 14:69,701,487 | C/G | — | uncertain significance |
| rs753769783 | 14:69,701,513 | G/A | — | uncertain significance |
| rs2043713005 | 14:69,701,522 | A/G | — | uncertain significance |
| rs2043716655 | 14:69,701,601 | G/C | — | uncertain significance |
| rs1253030104 | 14:69,701,666 | G/A | — | uncertain significance |
| rs368972120 | 14:69,701,699 | G/T | — | uncertain significance |
| rs1387688294 | 14:69,702,852 | T/C | — | uncertain significance |
| rs756329092 | 14:69,702,864 | T/C | — | uncertain significance |
| rs2503392181 | 14:69,703,169 | C/T | — | uncertain significance |
| rs146968535 | 14:69,703,183 | G/A | — | uncertain significance |
| rs758946926 | 14:69,703,217 | A/C | — | uncertain significance |
| rs4899292 | 14:69,704,052 | A/G | downstream gene variant | — |
| rs143178978 | 14:69,704,330 | C/G | — | uncertain significance |
| rs774538134 | 14:69,704,494 | C/T | — | uncertain significance |
| rs534330100 | 14:69,704,498 | G/A | — | uncertain significance |
| rs761327770 | 14:69,704,503 | G/C | — | uncertain significance |
| rs146099727 | 14:69,704,521 | G/A | — | uncertain significance |
| rs368454564 | 14:69,704,534 | C/T | — | uncertain significance |
| rs780087461 | 14:69,704,552 | A/G | — | uncertain significance |
| rs779208543 | 14:69,704,555 | G/A | — | uncertain significance |
| rs1406683196 | 14:69,704,601 | C/T | — | likely benign |
| rs184687038 | 14:69,705,564 | C/T | downstream gene variant | — |
| rs752738946 | 14:69,707,668 | C/T | — | uncertain significance |
| rs781476497 | 14:69,707,689 | A/G | — | uncertain significance |
| rs201072451 | 14:69,707,779 | C/T | — | uncertain significance |
| rs774071659 | 14:69,707,785 | T/G | — | uncertain significance |
| rs2503427177 | 14:69,707,798 | T/C | — | uncertain significance |
| rs1204250155 | 14:69,707,803 | A/G | — | uncertain significance |
| rs1043254 | 14:69,708,241 | G/A | 3 prime UTR variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.