rs212388

This is a upstream gene variant variant in the LOC112267968 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Crohn's disease

Liu JZ et al. “Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.” Nature Genetics 47(9):979-986 (2015)

Allele G

OR 1.11

p 2.0e-16

N 20,883

Large GWAS

multi-ancestry

Jostins L et al. “Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.” Nature 491(7422):119-24 (2012)

Allele G

OR 1.10

p 3.0e-14

N 34,366

Large GWAS

European

Franke A et al. “Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.” Nature Genetics 42(12):1118-25 (2010)

Allele G

OR 1.10

p 2.0e-11

N 21,389

Meta-analysisLarge GWAS

European

celiac disease, Crohn's disease

Festen EA et al. “A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease.” Plos Genetics 7(1):e1001283 (2011)

Allele C

OR —

p 2.0e-10

N 10,249

Meta-analysisLarge GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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