rs215226
This is a intron variant variant in the B4GALNT3 gene.
▶GWAS Catalog Trait Associations (7)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (7)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
sclerostin measurement
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.15
p 2.0e-220
N 47,745
Large GWAS
European
Zheng J et al. “Mendelian Randomization Analysis Reveals a Causal Influence of Circulating Sclerostin Levels on Bone Mineral Density and Fractures.” Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research 34(10):1824-1836 (2019)
Allele G
OR 0.20
p 5.0e-49
N 10,584
Large GWAS
European
heel bone mineral density
Morris JA et al. “An atlas of genetic influences on osteoporosis in humans and mice.” Nature Genetics 51(2):258-266 (2019)
Allele A
OR 0.02
p 3.0e-39
N 426,824
Large GWAS
European
level of tenascin-N in blood
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.03
p 1.0e-21
N 47,745
Large GWAS
European
health trait
Schoeler T et al. “Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline.” Nature Communications 16(1):4524 (2025)
Allele A
OR 0.01
p 3.0e-16
N 405,979
Large GWAS
European
bone fracture
Nethander M et al. “An atlas of genetic determinants of forearm fracture.” Nature Genetics 55(11):1820-1830 (2023)
Allele A
OR 1.04
p 1.0e-13
N 1,020,094
Large GWAS
European
collagenase 3 measurement
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.04
p 4.0e-12
N 47,745
Large GWAS
European
body height
Fernández-Rhodes L et al. “Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits-The Hispanic/Latino Anthropometry Consortium.” Hgg Advances 3(2):100099 (2022)
Allele A
OR 0.03
p 2.0e-9
N 59,771
Major Consortium StudyLarge GWAS
Hispanic or Latin American
About B4GALNT3
B4GALNT3 transfers N-acetylgalactosamine (GalNAc) onto glucosyl residues to form N,N-prime-diacetyllactosediamine (LacdiNAc, or LDN), a unique terminal structure of cell surface N-glycans (Ikehara et al., 2006 [PubMed 16728562]).[supplied by OMIM, Aug 2008]
View all B4GALNT3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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