rs2242285
This variant is located in the LRIG1 gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
atrial fibrillation
Yuan S et al. “Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation.” Nature Communications 16(1):6426 (2025)
Allele A
OR 0.04
p 1.0e-32
N 2,584,013
Large GWAS
multi-ancestry
heart function attribute
Sotoodehnia N et al. “Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.” Nature Genetics 42(12):1068-76 (2010)
Allele A
OR 0.37
p 1.0e-8
N 40,407
Large GWAS
European
QRS duration
Evans DS et al. “Fine-mapping, novel loci identification, and SNP association transferability in a genome-wide association study of QRS duration in African Americans.” Human Molecular Genetics 25(19):4350-4368 (2016)
Allele A
OR 0.37
p 5.0e-8
N 53,438
Large GWAS
multi-ancestry
About LRIG1
Predicted to act upstream of or within several processes, including innervation; otolith morphogenesis; and sensory perception of sound. Predicted to be located in plasma membrane. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
View all LRIG1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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