rs2271933

This is a protein-altering variant in the HCRTR1 gene.

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Research that mentions this SNP (1)

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Evidence of Syntaxin 1A Involvement in Migraine Susceptibility
ReviewCarolina Lemos et al.(2010)· Archives of Neurology

This review examines molecular genetic factors and biochemical markers associated with migraine, including genes encoding ion channels (KCNK18/TRESK), neurotransmitter systems (SLC6A4, HCRTR1), and metabolic enzymes (MTHFR C677T, rs1801133). The authors discuss polymorphisms in MTHFR, KCNK18, HCRTR1, SLC6A4, STX1A, GRIA1, and GRIA3, and report preliminary data from 68 Polish participants (34 patients, 34 controls) showing associations between 5-HTTLPR and HCRTR1 rs2271933 polymorphisms with migraine susceptibility and biochemical markers including serotonin and hypocretin-1 levels.

Traits studied:Familial hemiplegic migraineHomocysteine metabolismHypocretin-1 levelsMigraineMigraine with auraMigraine without auraOxidative stressPain transmissionSerotonin dysregulation
PubMedDOIMetascience Observatory

About HCRTR1

The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. [provided by RefSeq, Jan 2009]

View all HCRTR1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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