rs2278867

This variant is located in the MS4A6A gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

dementia

“A genome-wide association meta-analysis of all-cause and vascular dementia.” Alzheimer's & Dementia : the Journal of the Alzheimer's Association 20(9):5973-5995 (2024)

Allele A

OR 0.11

p 2.0e-15

N 524,852

Meta-analysisLarge GWAS

multi-ancestry

About MS4A6A

This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.1, among a cluster of family members. Alternative splicing of this gene results in several transcript variants that encode different protein isoforms. [provided by RefSeq, Oct 2011]

View all MS4A6A variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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