rs2282655

This variant is located in the PANX1 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Thyroid preparation use measurement

Wu Y et al. “Genome-wide association study of medication-use and associated disease in the UK Biobank.” Nature Communications 10(1):1891 (2019)

Allele T

OR 0.12

p 5.0e-11

N 305,582

Major Consortium StudyLarge GWAS

European

Hashimoto's thyroiditis

White SL et al. “Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.” Nature Genetics 58(2):307-316 (2026)

Allele T

OR 0.11

p 4.0e-8

N 1,815,514

Large GWAS

multi-ancestry

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ClinVar annotation

Benign★★★☆

3 submitters1 publication

not provided; Uterine carcinosarcoma; Thymoma; Cholangiocarcinoma; Acute myeloid leukemia

View on ClinVar →

About PANX1

The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]