rs2283725
This variant is located in the MAOA gene.
▶Research that mentions this SNP (1)
▶Monoamine oxidase A gene polymorphisms and enzyme activity associated with risk of gout in Taiwan aboriginesAssociationN=978Hung-Pin Tu et al.(2010)· Human Genetics
This case-control study in Taiwanese aborigines identified associations between MAOA gene polymorphisms and gout risk. Three MAOA SNPs (rs1137070 Asp470Asp, rs2283725, rs5953210) were significantly associated with gout, with rs1137070 showing the strongest association (OR=1.46, 95% CI: 1.11-1.91, P=4.0×10⁻⁵). The AGC haplotype was associated with a 1.67-fold increased risk (95% CI: 1.28-2.17). MAO-A enzyme activity correlated positively with gout risk (P for trend=2.00×10⁻³).
About MAOA
This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
View all MAOA variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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