rs2290883

This variant is located in the LRP4 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

cholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele G

OR 0.04

p 2.0e-9

N 115,082

Large GWAS

European

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ClinVar annotation

Benign★★★☆

5 submitters2 publications

Cenani-Lenz syndactyly syndrome; Congenital myasthenic syndrome 17;Sclerosteosis 2;Cenani-Lenz syndactyly syndrome; not provided; not specified

View on ClinVar →

About LRP4

This gene encodes a member of the low-density lipoprotein receptor-related protein family. The encoded protein may be a regulator of Wnt signaling. Mutations in this gene are associated with Cenani-Lenz syndrome. [provided by RefSeq, May 2010]

View all LRP4 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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