rs2297627

This variant is located in the FOXO1 gene.

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Research that mentions this SNP (1)

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AssessingFOXO1Aas a potential susceptibility locus for type 2 diabetes and obesity inAmericanIndians
AssociationN=7,710Yunhua L. Muller et al.(2015)· Obesity

In a population-based study of 7710 American Indians, the intronic SNP rs2297627 in FOXO1A associated with early-onset type 2 diabetes (OR=1.34, p=8.7×10^-4) and T2D at any age (OR=1.19, p=1×10^-4), with the risk allele also associated with lower acute insulin secretion (β=0.88, p=0.02). Another intronic SNP rs1334241 (in high LD with rs2297627) associated with maximum adult BMI (β=1.02, p=3×10^-5) and childhood BMI z-score (β=0.08, p=3×10^-4). These findings suggest FOXO1A variation may modestly affect T2D risk and obesity susceptibility in American Indians.

Traits studied:Body fat percentageBody mass indexInsulin secretionObesityType 2 diabetes
PubMedDOIMetascience Observatory

About FOXO1

This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008]

View all FOXO1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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