rs2305158
This is a coding sequence variant variant in the NPAS2 gene.
▶Research that mentions this SNP (1)
▶Functional polymorphisms in circadian positive feedback loop genes predict postsurgical prognosis of gastric cancerAssociationN=704Yibing Chen et al.(2019)· Cancer Medicine
This association study examined nine functional SNPs in circadian positive feedback loop genes (CLOCK, BMAL1, NPAS2) in 704 Chinese gastric cancer patients. Three SNPs showed significant associations with overall survival and recurrence-free survival: rs11133399 in CLOCK (HR 1.27-1.29, p=0.007-0.020), rs2279284 in BMAL1 (HR 1.12-1.18, p=0.024-0.048), and rs1044432 in BMAL1 (HR 0.82-0.84, p=0.042-0.047). Functional assays confirmed that the G allele of rs11133399 enhanced CLOCK promoter activity and gene expression.
About NPAS2
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. [provided by RefSeq, Jul 2008]
View all NPAS2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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