rs2316205

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

nicotine metabolite ratio

Patel YM et al. “Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk.” Cancer Research 76(19):5768-5776 (2016)

Allele C

OR 0.18

p 4.0e-14

N 2,239

Large GWAS

multi-ancestry

cotinine measurement

Buchwald J et al. “Genome-wide association meta-analysis of nicotine metabolism and cigarette consumption measures in smokers of European descent.” Molecular Psychiatry 26(6):2212-2223 (2021)

Allele T

OR 0.14

p 1.0e-11

N 5,185

Meta-analysis

European

linoleic acid measurement

Sun Y et al. “GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.” Hgg Advances 6(4):100470 (2025)

Allele C

OR —

p 7.0e-9

N 239,268

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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