rs2384060

This variant is located in the ADCY3 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

obese body mass index status

Riveros-McKay F et al. “Genetic architecture of human thinness compared to severe obesity.” Plos Genetics 15(1):e1007603 (2019)

Allele G

OR 1.14

p 9.0e-23

N 7,916

Large GWAS

European

body height

Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)

Allele G

OR 0.02

p 2.0e-15

N 153,950

Large GWAS

East Asian

About ADCY3

This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

View all ADCY3 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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