rs2407746

This is a intergenic variant variant.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

neuroticism measurement

Nagel M et al. “Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.” Nature Genetics 50(7):920-927 (2018)
Allele C
OR 7.01
p 2.0e-12
N 449,484
Meta-analysisLarge GWAS
European
Nagel M et al. “Item-level analyses reveal genetic heterogeneity in neuroticism.” Nature Communications 9(1):905 (2018)
Allele C
OR 6.95
p 4.0e-12
N 380,506
Large GWAS
European
Kim Y et al. “Genetic and neural bases of the neuroticism general factor.” Biological Psychology 184:108692 (2023)
Allele C
OR 0.01
p 7.0e-11
N 380,000
Large GWAS
Nagel M et al. “Genome-wide association study of the sensitivity to environmental stress and adversity neuroticism cluster.” Acta Psychiatrica Scandinavica 141(5):476-478 (2020)
Allele C
OR —
β 0.016
p 3.0e-10
N 351,827
Large GWAS
European
Luciano M et al. “Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism.” Nature Genetics 50(1):6-11 (2018)
Allele C
OR 5.91
p 3.0e-9
N 329,821
Large GWAS
European

Anxiety

Nagel M et al. “Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.” Nature Genetics 50(7):920-927 (2018)
Allele G
OR 0.02
p 1.0e-10
N 348,219
Meta-analysisLarge GWAS
European

feeling nervous measurement

Nagel M et al. “Item-level analyses reveal genetic heterogeneity in neuroticism.” Nature Communications 9(1):905 (2018)
Allele C
OR 5.93
p 3.0e-9
N 373,121
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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