rs2414577
This is a intron variant variant.
▶GWAS Catalog Trait Associations (12)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (12)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
1-stearoyl-2-oleoyl-GPE (18:0/18:1) measurement
Chen Y et al. “Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.” Nature Genetics 55(1):44-53 (2023)
Allele C
OR 0.23
p 7.0e-47
N 8,273
Large GWAS
European
LDL particle size
Li-Gao R et al. “Genetic Studies of Metabolomics Change After a Liquid Meal Illuminate Novel Pathways for Glucose and Lipid Metabolism.” Diabetes 70(12):2932-2946 (2021)
Allele C
OR 0.26
p 1.0e-31
Large GWAS
triglyceride measurement, high density lipoprotein cholesterol measurement
Li-Gao R et al. “Genetic Studies of Metabolomics Change After a Liquid Meal Illuminate Novel Pathways for Glucose and Lipid Metabolism.” Diabetes 70(12):2932-2946 (2021)
Allele C
OR 0.23
p 3.0e-24
Large GWAS
level of phosphatidylethanolamine
Huang Y et al. “Genetic factors shaping the plasma lipidome and the relations to cardiometabolic risk in children and adolescents.” Ebiomedicine 112:105537 (2025)
Allele C
OR 0.42
p 8.0e-21
N 1,149
Large GWAS
European
cholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement
Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)
Allele T
OR 0.04
p 9.0e-21
N 115,082
Large GWAS
European
remnant cholesterol measurement, high density lipoprotein cholesterol measurement
Li-Gao R et al. “Genetic Studies of Metabolomics Change After a Liquid Meal Illuminate Novel Pathways for Glucose and Lipid Metabolism.” Diabetes 70(12):2932-2946 (2021)
Allele C
OR 0.18
p 1.0e-15
Large GWAS
polyunsaturated fatty acids to total fatty acids percentage
Sun Y et al. “GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.” Hgg Advances 6(4):100470 (2025)
Allele C
OR —
p 3.0e-15
N 239,268
Large GWAS
European
erythrocyte count
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.02
p 4.0e-12
N 581,817
Major Consortium StudyLarge GWAS
multi-ancestry
metabolite measurement
Chen Y et al. “Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.” Nature Genetics 55(1):44-53 (2023)
Allele C
OR 0.12
p 4.0e-11
N 6,804
Large GWAS
European
level of phosphatidylcholine
Lotta LA et al. “A cross-platform approach identifies genetic regulators of human metabolism and health.” Nature Genetics 53(1):54-64 (2021)
Allele C
OR 6.29
p 3.0e-10
N 16,839
Large GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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