rs2466035

This variant is located in the CASC19 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

chronic lymphocytic leukemia

Berndt SI et al. “Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.” Nature Genetics 45(8):868-76 (2013)
Allele C
OR 1.21
p 2.0e-8
N 8,400
Large GWAS
European
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Research that mentions this SNP (1)

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Common genetic variants in the 8q24 region and risk of papillary thyroid cancer
AssociationN=796Gila Neta et al.(2012)· The Laryngoscope

This case-control study evaluated 157 tag SNPs in the 8q24 chromosomal region in relation to papillary thyroid cancer (PTC) risk using 344 PTC cases and 452 controls. While previously cancer-associated SNPs (rs1562430, rs1447295, rs6983267) showed no significant association with PTC, one SNP (rs4733616, P=0.003) and 12 others showed uncorrected P<0.05 associations; however, none remained significant after false discovery rate correction, suggesting no strong association between 8q24 variants and sporadic PTC risk.

Traits studied:Bladder cancerBreast cancerChronic lymphocytic leukemiaColorectal cancerPapillary thyroid cancerProstate cancerUrinary cancer
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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