rs2501431

This study investigated genetic variation in the endocannabinoid system (CNR1, CNR2, FAAH genes) as a predictor of response to cognitive behavior therapy for childhood anxiety disorders in 1,309 children aged 5-17 years. Six SNPs showed nominal associations (P<0.05) with treatment response during follow-up: rs806365 (CNR1, P=0.004), rs2501431 (CNR2), rs2070956 (CNR2), rs7769940 (CNR1), rs2209172 (FAAH) associated with poorer response, and rs6928813 (CNR1) with better response. Only rs806365 survived multiple testing corrections in the fear-based anxiety disorder subset (P=0.0011). The authors conclude there is very limited evidence for genetic variation in endocannabinoid system genes predicting CBT treatment response.

This case-control study evaluated 39 SNPs in the CNR2 gene for association with bone mineral density (BMD) and osteoporosis in 1,032 postmenopausal osteoporosis patients and 2,089 healthy Han Chinese controls. Two SNPs (rs4237 and rs2501431) were significantly associated with osteoporosis, with rs4237 showing p=0.000515 and rs2501431 showing p=0.000441, both with odds ratios around 1.2. Haplotype analysis identified five haplotypes with significant associations, particularly HAP9 which showed 4-fold increased frequency in cases (p<0.001).