CNR2
cannabinoid receptor 2
Summary
The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]
Known Variants36 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs4285654 | 1:24,196,683 | C/T | upstream gene variant | — |
| rs138396102 | 1:24,197,196 | C/A | upstream gene variant | — |
| rs2502995 | 1:24,199,290 | T/C | regulatory region variant | — |
| rs2501426 | 1:24,199,364 | G/A | regulatory region variant | — |
| rs3003334 | 1:24,199,869 | G/A | 3 prime UTR variant | — |
| rs2229586 | 1:24,200,903 | G/C | 3 prime UTR variant | — |
| rs778618350 | 1:24,201,084 | C/A | — | uncertain significance |
| rs2521816298 | 1:24,201,107 | C/A | — | uncertain significance |
| rs751574405 | 1:24,201,125 | G/A | — | uncertain significance |
| rs761834077 | 1:24,201,151 | C/G | — | uncertain significance |
| rs2229579 | 1:24,201,162 | G/A | missense variant | — |
| rs201210941 | 1:24,201,169 | G/A | — | benign |
| rs191065191 | 1:24,201,203 | C/T | — | uncertain significance |
| rs3003336 | 1:24,201,448 | C/T | synonymous variant | — |
| rs142861964 | 1:24,201,513 | C/T | — | uncertain significance |
| rs767181446 | 1:24,201,551 | A/T | — | uncertain significance |
| rs201087852 | 1:24,201,633 | C/A | — | uncertain significance |
| rs2501431 | 1:24,201,643 | G/A | synonymous variant | — |
| rs41311993 | 1:24,201,711 | G/T | missense variant | — |
| rs767985981 | 1:24,201,778 | A/C | — | uncertain significance |
| rs144279977 | 1:24,201,817 | G/A | — | likely benign |
| rs1414556125 | 1:24,201,891 | T/A | — | uncertain significance |
| rs141481878 | 1:24,201,900 | A/G | — | uncertain significance |
| rs61996280 | 1:24,201,911 | C/T | — | benign |
| rs2502992 | 1:24,201,919 | T/C | synonymous variant | — |
| rs2501432 | 1:24,201,920 | T/G | missense variant | — |
| rs1301116696 | 1:24,201,927 | A/G | — | uncertain significance |
| rs950189696 | 1:24,201,986 | G/A | — | uncertain significance |
| rs201821646 | 1:24,202,019 | C/T | — | uncertain significance |
| rs751752206 | 1:24,202,042 | C/T | — | uncertain significance |
| rs755226163 | 1:24,202,044 | T/C | — | uncertain significance |
| rs1443162077 | 1:24,202,048 | G/T | — | uncertain significance |
| rs142134658 | 1:24,202,065 | C/A | — | uncertain significance |
| rs201016971 | 1:24,202,070 | G/A | — | uncertain significance |
| rs2501401 | 1:24,220,063 | A/C | — | — |
| rs61778217 | 1:24,229,413 | G/A | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.