rs2502992
This is a synonymous variant in the CNR2 gene — it does not change the protein's amino acid sequence.
▶Research that mentions this SNP (1)
▶Evaluation of common variants in CNR2 gene for bone mineral density and osteoporosis susceptibility in postmenopausal women of Han ChineseAssociationN=3,121Zhang C. et al.(2015)· Osteoporosis International
This case-control study evaluated 39 SNPs in the CNR2 gene for association with bone mineral density (BMD) and osteoporosis in 1,032 postmenopausal osteoporosis patients and 2,089 healthy Han Chinese controls. Two SNPs (rs4237 and rs2501431) were significantly associated with osteoporosis, with rs4237 showing p=0.000515 and rs2501431 showing p=0.000441, both with odds ratios around 1.2. Haplotype analysis identified five haplotypes with significant associations, particularly HAP9 which showed 4-fold increased frequency in cases (p<0.001).
About CNR2
The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]
View all CNR2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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