rs2550298

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

chronotype measurement

Jones SE et al. “Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms.” Nature Communications 10(1):343 (2019)
Allele C
OR 1.04
p 6.0e-26
N 403,195
Large GWAS
European
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Research that mentions this SNP (1)

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The relationship of deiodinase 1 genotype and thyroid function to lifetime history of major depression in three independent populations
AssociationN=1,555Robert A. Philibert et al.(2011)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

This candidate gene study examined 12 SNPs from genome-wide association studies of thyroid function in 1,555 subjects from three independent cohorts, testing associations with major depression and thyroid hormones. The authors confirmed that the DIO1 variant rs11206244 (T allele) was associated with increased free thyroxine (FT4) levels in both ethnic groups (p<0.004 in White females). Notably, rs11206244 genotype was associated with lifetime major depression in White female subjects from high-risk cohorts (p<0.004), but not in African American subjects or White males. Current FT4 levels were not associated with lifetime depression, suggesting thyroid changes in depression are state-dependent rather than trait-dependent.

Traits studied:Free thyroxine (FT4)Major depressionThyroid functionThyroid stimulating hormone (TSH)
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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