rs2563298

This functional study investigates the molecular mechanisms of the CD14 rs2569190 polymorphism in peripheral blood mononuclear cells using chromatin immunoprecipitation and allele-specific transcript quantification. The T allele of rs2569190 showed approximately twice the recruitment of serine-5-phosphorylated RNA polymerase II compared to the C allele, suggesting enhanced transcription initiation; however, transcript abundance was similar between alleles. The findings indicate that rs2569190 affects transcription initiation but not mRNA expression levels in PBMC, and suggest that endotoxin sensitivity associated with this polymorphism may depend on tissue-specific effects in hepatic or other cell types rather than myeloid CD14 expression.