CD14
CD14 molecule
Summary
The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide, and to viruses. This gene has been identified as a target candidate in the treatment of SARS-CoV-2-infected patients to potentially lessen or inhibit a severe inflammatory response. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2020]
Known Variants33 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2563298 | 5:140,011,315 | C/A | 3 prime UTR variant | — |
| rs4914 | 5:140,011,468 | C/A | synonymous variant | — |
| rs375045420 | 5:140,011,494 | C/T | — | uncertain significance |
| rs375420920 | 5:140,011,544 | C/T | — | likely benign |
| rs11556179 | 5:140,011,548 | C/T | — | likely benign |
| rs924829671 | 5:140,011,549 | G/T | — | likely benign |
| rs368708682 | 5:140,011,551 | G/A | — | uncertain significance |
| rs750069399 | 5:140,011,646 | C/T | — | uncertain significance |
| rs1427874428 | 5:140,011,648 | G/T | — | uncertain significance |
| rs560447529 | 5:140,011,743 | T/C | — | uncertain significance |
| rs2481042305 | 5:140,011,769 | G/A | — | uncertain significance |
| rs764093281 | 5:140,011,817 | G/C | — | uncertain significance |
| rs74587733 | 5:140,011,867 | C/T | — | benign |
| rs990651766 | 5:140,011,872 | C/G | — | uncertain significance |
| rs2481044391 | 5:140,012,009 | C/G | — | uncertain significance |
| rs533188543 | 5:140,012,114 | A/T | — | uncertain significance |
| rs144018386 | 5:140,012,131 | G/A | — | benign |
| rs749280741 | 5:140,012,135 | G/T | — | uncertain significance |
| rs759809666 | 5:140,012,141 | G/C | — | uncertain significance |
| rs1756630550 | 5:140,012,188 | C/A | — | uncertain significance |
| rs142233870 | 5:140,012,229 | C/T | — | uncertain significance |
| rs1460615098 | 5:140,012,237 | C/T | — | uncertain significance |
| rs202080106 | 5:140,012,277 | C/A | — | uncertain significance |
| rs201545309 | 5:140,012,304 | G/A | — | uncertain significance |
| rs2481046794 | 5:140,012,363 | A/C | — | uncertain significance |
| rs2569190 | 5:140,012,916 | A/G | regulatory region variant | — |
| rs5744455 | 5:140,013,307 | G/T | — | — |
| rs75652866 | 5:140,013,431 | G/C | downstream gene variant | — |
| rs5744454 | 5:140,013,567 | T/G | downstream gene variant | — |
| rs5744451 | 5:140,013,883 | A/C | downstream gene variant | — |
| rs2569191 | 5:140,013,903 | C/A | — | — |
| rs2915863 | 5:140,014,377 | C/T | upstream gene variant | — |
| rs190828983 | 5:140,014,431 | G/A | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.